What we do

Antibodies are critical for adaptive immunity and represent the primary correlate of protection for most vaccines. They are also an important type of therapeutic with rapidly growing demand.

We utilize various technologies and approaches to study autoimmunity, B cell biology, and immune responses to infectious diseases in humans and mice, with a special focus on influenza vaccinology. The Wilson laboratory typically investigates B cell questions from a “specificity-first” perspective by characterizing B cell and monoclonal antibody specificities to interpret immune responses or assess B cell tolerance. Our recent work has involved extensive use of single-cell transcriptomics combined with cell surface and antigen-binding techniques using oligonucleotide hash-tagging. We then employ multiple methods and technologies to further characterize the B cells and antibodies involved in these responses.

Activities

News

Congratulations, Patrick!

Posted on December 9, 2024

Congratulations to Patrick Wilson, who was awarded “Highly Cited Researcher” status on the Clarviate Web of Science! See Patrick’s citation metrics and publications here.

Congratulations, Tomi!

Posted on April 3, 2024

Tomi McGuire, rotating grad student from January to March, 2024, shown here presenting her poster. Tomi investigated using computational methods to call specificity and poly-reactivity in B-cells. [Read More]

2024 Drukier Lecture and Prize!

Posted on February 20, 2024

On February 13, 2024, the Wilson Lab attended the 2024 Gale and Ira Drukier Lecture in Children’s Health, featuring Carola Vinuesa, M.D., Ph.D., who spoke about “The B Cell’s Tale”. Sumit Gupta, M.D., Ph.D., the 2023 recipient of the Gale and Ira Drukier Prize in Children’s Health Research, also gave... [Read More]

2023 Annual Conferences

Posted on September 1, 2023

This August featured two annual conferences that Wilson Lab Members attended. First, was the CIVIC Annual Meeting held in Florida. [Read More]

November News

Posted on April 25, 2023

There are several major lab updates from this past November! First, we congratulate Patrick for being named the Anne E. Dyson Professor of Pediatric Research. [Read More]

Congratulations, Siri!

Posted on March 11, 2023

Congratulations to Siri Changrob, for being awarded the winner of the 2022 post-doc research day poster presentation (9/19/22) and for receiving the distinguished young alumni award from Prince of Songkla University (3/11/23)!

New this week in the JAMA Network Medical News!

Posted on January 26, 2022

Dr. Wilson provides context to a recent study investigating the potential role of pre-existing seasonal coronaviral antibodies in limiting de novo, protective SARS-CoV-2-specific immunity. JAMA Network

Jiayi Sun joins the lab as a postdoc. Welcome!

Posted on March 4, 2021

He previously completed his PhD at the Committee on Microbiology at the University of Illinois at Urbana-Champaign, with a thesis titled, “Influenza A virus gene expression heterogeneity regulates viral superinfection potential and host innate anti-viral response” [Read More]

First place in the 2015 drink competition!

Posted on December 11, 2015

Our rendition of affinity maturation, which includes competition for antigen (“antibody pong”), death by neglect (a shot of Malört), affinity maturation (a raspberry Chambord cocktail), and DEC-205 (Michel Nussenzweig’s “golden ticket”), won this year’s immunology drink competition! [Read More]