What we do
Antibodies are critical for adaptive immunity and represent the primary correlate of protection for most vaccines. They are also an important type of therapeutic with rapidly growing demand.
The antibody biology lab, headed by Patrick Wilson, studies various aspects of antibody-mediated immunity. These topics include antibody-mediated immunity to infectious diseases such as influenza, anthrax, pneumococcal and staphylococcal bacteria. We also study the function of B cells, the development of B cell immune responses, antibody gene usage and diversification, and B cell tolerance.
Activities
I am tweeting (@PatWilsonLab1)
News
On May 22, 2024, Jiayi and Josh represented the Wilson Lab by presenting their research at Pediatrics Research Day!
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Congratulations, Tomi!
Tomi McGuire, rotating grad student from January to March, 2024, shown here presenting her poster. Tomi investigated using computational methods to call specificity and poly-reactivity in B-cells.
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2024 Drukier Lecture and Prize!
On February 13, 2024, the Wilson Lab attended the 2024 Gale and Ira Drukier Lecture in Children’s Health, featuring Carola Vinuesa, M.D., Ph.D., who spoke about “The B Cell’s Tale”. Sumit Gupta, M.D., Ph.D., the 2023 recipient of the Gale and Ira Drukier Prize in Children’s Health Research, also gave...
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2023 Annual Conferences
This August featured two annual conferences that Wilson Lab Members attended. First, was the CIVIC Annual Meeting held in Florida.
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November News
There are several major lab updates from this past November! First, we congratulate Patrick for being named the Anne E. Dyson Professor of Pediatric Research.
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Congratulations, Siri!
Congratulations to Siri Changrob, for being awarded the winner of the 2022 post-doc research day poster presentation (9/19/22) and for receiving the distinguished young alumni award from Prince of Songkla University (3/11/23)!
Atsuhiro YASUHARA joins the lab as a postdoc. Welcome!
Welcome, Atsu!
New this week in the JAMA Network Medical News!
Dr. Wilson provides context to a recent study investigating the potential role of pre-existing seasonal coronaviral antibodies in limiting de novo, protective SARS-CoV-2-specific immunity. JAMA Network
Joshua McGrath joins the lab as a postdoc. Welcome!
Welcome, Josh!
The Wilson lab is moving to Weill Cornell Medicine
We’re moving to Gale and Ira Drukier Institute for Children’s Health, Weill Cornell Medicine, NYC! See you in New York!
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Haley defends her thesis! Congratulations, Dr. Dugan!
Congratulations, Dr. Dugan!
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Chris defends his thesis! Congratulations, Dr. Stamper!
Congratulations, Dr. Stamper!
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Jiayi Sun joins the lab as a postdoc. Welcome!
He previously completed his PhD at the Committee on Microbiology at the University of Illinois at Urbana-Champaign, with a thesis titled, “Influenza A virus gene expression heterogeneity regulates viral superinfection potential and host innate anti-viral response”
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Yanbin Fu joins the lab as a postdoc. Welcome!
He previously worked on the role of myeloid-derived suppressor cells in the process of anti-tumor immunity at the University of Chicago.
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Steven Erickson joins the lab as a postdoc. Welcome!
He previously completed his PhD at the Committee on Immunology at the University of Chicago, with a thesis titled, “A novel B-1b precursor stage in the peritoneal cavity.”
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Jiaolong Wang joins the lab as research staff. Welcome!
He previously worked on preclinical development of myosolvins as a new class of medicine for asthma at the University of Chicago.
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Isabelle Stewart joins the lab as a postdoc. Welcome!
She previously completed her PhD at the Weatherall Institute of Molecular Medicine, at the University of Oxford.
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Siri Changrob joins the lab as a postdoc. Welcome!
She previously worked on immune responses to malaria and malaria vaccine candidates in Patchanee Chootong’s lab at Mahidol University.
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Patrick is interviewed by JAMA about universal flu vaccine development
Watch the JAMA Network video about advances toward a universal flu vaccine, featuring an interview with Patrick and footage of Wilson Lab members conducting their work!
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First place in the 2015 drink competition!
Our rendition of affinity maturation, which includes competition for antigen (“antibody pong”), death by neglect (a shot of Malört), affinity maturation (a raspberry Chambord cocktail), and DEC-205 (Michel Nussenzweig’s “golden ticket”), won this year’s immunology drink competition!
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Sarah publishes her paper in Science Translational Medicine
Read about the impact of immune history on broadly protective influenza vaccine responses!
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Patrick co-edits a theme issue about antibody dynamics for Phil. Trans. R. Soc. B!
Now available online!
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Chris Stamper, an immunology graduate student, joins the lab. Welcome!
Welcome, Chris!
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Carole publishes a review on stereotyped B cell responses in Phil. Trans. R. Soc. B
Read more.
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Lyubov Popova joins as a postdoc. Welcome!
She previously worked on influenza antigenic sites in Gillian Air’s lab at the University of Oklahoma.
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Kaval defends her thesis! Congratulations, Dr. Kaur!
Congratulations, Dr. Kaur!
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Patrick co-organizes the Keystone symposium for the Golden Anniversary of B Cell Discovery in Banff, Canada
Carole’s paper on existing protection against avian H7N9 is published in the Journal of Clinical Investigation
Read it here!
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Noel successfully defends. Congratulations, Dr. Pauli!
Congratulations, Dr. Pauli!
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Sarah’s paper on the impact of pre-existing protection on vaccine responses is published in the Journal of Virology
Read it here!
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Wilson Lab places third in the 2014 drink competition!
We had a blast building and showing off our own version of a FACS (Fluorescence-activated cocktail sorting) machine! It runs on a Raspberry Pi and uses a solenoid valve to dispense our drink on-demand.
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Noel’s paper on S. aureus immune evasion is published in the Journal of Experimental Medicine. Congratulations!
Noel publishes his thesis work! The paper is featured in two commentaries, in Nature and J Exp Med.
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Sarah Andrews finishes her postdoc. Good luck at the NIH, Sarah!
Good luck at the NIH, Sarah!
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Yaoqing Chen joins the lab as a postdoc. Welcome!
Previously, Yaoqing worked on the crystal structures of viral receptor binding domains in the lab on Fang Li at the University of Minnesota.
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